Alipal, J. and Saidin, S. and Kai Lo, A.Z. and Koshy, P. and Abdullah, H.Z. and Idris, M.I. and Lee, T.C. (2023) In vitro surface efficacy of CaP-based anodised titanium for bone implants. Surfaces and Interfaces, 39. pp. 1-21.
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Abstract
This study examined the effect of changes to the surface of CaP-based anodised titanium on osteogenesis and antimicrobial activity in vitro. The present work is proposed to investigate the mechanical stability of two different CaP/TiO2 micromorphology-based coatings, namely donut-shaped (350 V) and needle-shaped (450 V), that are fabricated by single-step micro-arc anodic oxidation at different conditions alongside with their cytocompatibility and antibacterial properties. The microhardness of the sample anodised at 450 V is ~100 MPa lower than that seen in the sample fabricated at 350 V, but both resultant coatings were strongly adhere to the substrate. However, the coating at 450 V was observed to suffer from delamination, indicating the needle-like structure is mechanically unstable. After 7 days of SBF immersion, the 450 V sample was highly bioactive relative to the 350 V sample. However, MTT assays showed that the 450 V coatings showed lower growth rate of hFOB 1.19 at day 14, which indicates that although the structure does have a superior ability to form apatite, it has long-term negative implications possibly from the toxicity of the structure to bone growth. The Alizarin-red staining shows that 450 V sample shows a negative trend of osteogenic mineralisation, thus qualitatively validating the toxicity. For antimicrobial effects, the donut-shaped microstructures were shown to have adequate antibacterial properties compared to the needle-like structures. Overall, this study suggest that the donut-shaped TiO2 morphology is the best cementless interface for bone cell anchorage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Anodic oxidationTitanium Bone anchorage Calcium phosphate coating Antimicrobial Cytotoxicity |
| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Engineering Technology > Department of Chemical Engineering Technology |
| Depositing User: | Mr. Mohamad Zulkhibri Rahmad |
| Date Deposited: | 25 Sep 2023 01:47 |
| Last Modified: | 25 Sep 2023 01:47 |
| URI: | http://eprints.uthm.edu.my/id/eprint/10009 |
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