Anti-gout potential of Malaysian medicinal plants

Abu Bakar, Fazleen I. and Abu Bakar, Mohd F. and Rahmat, Asmah and Abdullah, Norazlin and Sabran, Siti F. and Endrini, Susi (2018) Anti-gout potential of Malaysian medicinal plants. Frontiers in Pharmacology, 9 (261). pp. 1-14. ISSN 16639812

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Official URL: https://doi.org/10.3389/fphar.2018.00261

Abstract

Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated.

Item Type:Article
Uncontrolled Keywords:Xanthine oxidase inhibition; anti-gout; phytochemical; Malaysian medicinal plants; in vitro; in vivo
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty of Applied Science and Technology > Department of Technolgy and Heritage
ID Code:11169
Deposited By:Mr. Mohammad Shaifulrip Ithnin
Deposited On:13 May 2019 09:12
Last Modified:13 May 2019 09:12

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