Fabrication of PDMS-Based Microdilution Chip using Masked Stereolithography (MSLA) 3D Printed Mold

Noridin, Muhammad Al Aziim and Othman, Nurmiza and Zaina, Nurfarina and Soon, Chin Fhong and Winantyo, Rangga and Abdul Hamid, Intan Sue Liana (2025) Fabrication of PDMS-Based Microdilution Chip using Masked Stereolithography (MSLA) 3D Printed Mold. Journal of Advanced Research in Micro and Nano Engineering, 29 (1). pp. 60-70. ISSN 2756-8210

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Abstract

An alternative fabrication method for microdilution chips that address the limitations of traditional methods and ensures transparency, chemical resistance, and biocompatibility is presented in this paper. This work describes the design, fabrication, and characterization of the microdilution chip using mask stereolithography (MSLA) 3D printed mold. The microdilution chip fabrication uses the 3D printed mold for replication in the soft lithography method to produce the polydimethylsiloxane (PDMS)- based final chip. The height of the microdilution chip channel differs by 8% between the MSLA 3D printed mould and the design dimension in software and by 12% between the MSLA 3D printed mould and the PDMS-replicated microdilution chip. The MSLA 3D printer generates trustworthy resolution outputs with a channel width error margin of 50 μm. Two distinct pH solutions are used to successfully test the microdilution devices and show dilution for all outlets.

Item Type:	Article
Uncontrolled Keywords:	Microfluidic chip; microdilution; masked stereolithography (MSLA) 3D print; polydimethylsiloxane (PDMS)
Subjects:	T Technology > TJ Mechanical engineering and machinery
Divisions:	Faculty of Electrical and Electronic Engineering > FKEE
Depositing User:	Mr. Mohamad Zulkhibri Rahmad
Date Deposited:	06 Aug 2025 03:31
Last Modified:	06 Aug 2025 03:31
URI:	http://eprints.uthm.edu.my/id/eprint/12865

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