Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds

Ramli, Roslinda Hani and Soon, Chin Fhong and Ahmad, Mohd Khairul and Nayan, Nafarizal and Mohd Rus, Anika Zafiah (2019) Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds. In: Current Advances in Microdevices and Nanotechnology. Penerbit Uthm, Uthm, pp. 131-147. ISBN 978-967-2306-25-2

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Abstract

A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Alginate (Alg) and chitosan (Chi) are both popular materials applied as biomaterials or bioimplants. However, Alg derived from brown algae is highly compliant and easily decomposed in fluid, whilst Chi derived from shrimp shells has weak strength. In rectify these problems, the development of Chi and Alg based biodegradable scaffolds incorporated with silver nanoparticles (AgNPs) with enhanced mechanical properties and biosafe function is proposed. Different ratios of chitosan/alginate (Chi/Alg) were prepared and the effect of different ratio (1:1, 1:2 and 2:1) to the mechanical with and without AgNPs were investigated. Meanwhile, swelling/degradation test and dynamic mechanical analysis (DMA) were conducted to study the properties of Chi/Alg based scaffold. Swelling/degradation test and DMA show that Chi/Alg and chitosan/alginate/silver (Chi/Alg/AgNPs) nanoparticles has adequate swelling and compressive modulus that exceed the epidermis’ Young modulus, thus able to provide mechanical support upon application. As a result, the incorporation of chitosan in the Alg and AgNPs improved physical and mechanical properties of hydrogel itself and provide biosafe environment during the study. Keywords: bio-composite, silver nanoparticles, alginate, chitosan, hydrogel, mechanical properties

Item Type:	Book Section
Uncontrolled Keywords:	nil
Subjects:	T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800-8360 Electronics
Divisions:	Faculty of Electrical and Electronic Engineering > Department of Electronic Enngineering
Depositing User:	Mr. Mohd Iskandar Faiz Amran
Date Deposited:	10 Jan 2022 03:41
Last Modified:	10 Jan 2022 03:41
URI:	http://eprints.uthm.edu.my/id/eprint/3579

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