Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite

Jian, Wang and Zakaria, Nor Hidayah and Abd Razak, Saiful Izwan and Abdul Kadir, Mohammed Rafiq and Mat Nayan, Nadirul Hasraf and Li, Yi and Mat Amin, Khairul Anuar (2018) Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite. Composite Interfaces, 26 (2011). 0927-6440. ISSN 0927-6440

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Abstract

This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (CLSM) images showed existence of chitosan entrapment with depth of 24 μm. Immersion of the modified PLA scaffold in simulated body fluid resulted in formation of apatite layers on the surface. Plus the entrapment method does not induce any cytotoxic response towards human fibroblast cell. This method provides a facile approach of obtaining 3D printed scaffold with good bioactivity thus has potential in biomimetic and tissue engineering.

Item Type:	Article
Uncontrolled Keywords:	Scaffold; 3D printing; entrapment; chitosan; surface modification; simulated body fluid; polylactic acid (PLA)
Subjects:	T Technology > TP Chemical technology > TP200-248 Chemicals: Manufacture, use, etc.
Divisions:	Faculty of Engineering Technology > Department of Chemical Engineering Technology
Depositing User:	UiTM Student Praktikal
Date Deposited:	07 Dec 2021 03:58
Last Modified:	07 Dec 2021 03:58
URI:	http://eprints.uthm.edu.my/id/eprint/4476

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