Preparation of the electrospun polyvinylidene fluoride / polyvinyl alcohol scaffold as a potential tissue replacement

Hamzah, Mohd Syahir Anwar and Ab Razak, Nurul Amira and Ng, Celine and Abdul Azize, Akmal Hafiszi and Abdul Sukor, Jumadi and Soon, Chin Fhong and Idris, Mohd Safiee and Mat Nayan, Nadirul Hasraf (2020) Preparation of the electrospun polyvinylidene fluoride / polyvinyl alcohol scaffold as a potential tissue replacement. IIUM Engineering Journal, 22 (1). ISSN 1511-758x

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Official URL: https://doi.org/10.31436/iiumej.v22i1.1548

Abstract

Polyvinylidene fluoride (PVDF), a piezoelectric material, is commonly used in tissue engineering due to its potential for mimicking the electrical microenvironment of biological conditions for tissue development. In this present research, polyvinyl alcohol (PVA) was introduced into electrospun PVDF fabrication through an electrospinning process, aiming to enhance the nanofibrous membrane's biocompatibility properties by improving the hydrophilicity properties to act as an artificial tissue scaffold. The electrospun PVDF/PVA membranes are found to be optimum at a PVDF-to-PVA ratio of 90:10 due to its excellent mechanical, morphological, and hydrophilicity conductivity properties. Fourier transform infrared (FTIR) spectroscopy verified strong hydrogen bonding interaction formed between the fluorine group of PVDF with oxygen-containing in the hydroxyl group of PVA. In-vitro cell culture showed that the enhanced hydrophilic property of electrospun PVDF/PVA could significantly enhance the cell growth. These positive results indicated that the scaffold could be implemented as artificial tissue material for tissue engineering applications.

Item Type:	Article
Uncontrolled Keywords:	Polyvinylidene fluoride; polyvinyl alcohol; electrospinning; tissue engineering; nanofibre scaffold
Subjects:	T Technology > TP Chemical technology > TP250-261 Industrial electrochemistry
Divisions:	Faculty of Engineering Technology > Department of Chemical Engineering Technology
Depositing User:	Mr. Abdul Rahim Mat Radzuan
Date Deposited:	30 Jan 2022 03:16
Last Modified:	30 Jan 2022 03:16
URI:	http://eprints.uthm.edu.my/id/eprint/6332

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