A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective

Wsoo, Mohammed Ahmad and Shahir, Shafinaz and Mohd Bohari, Siti Pauliena and Mat Nayan, Nadirul Hasraf and Abd Razak, Saiful Izwan (2020) A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective. Carbohydrate Research, 491. pp. 1-12. ISSN 0008-6215

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Abstract

Cellulose acetate (CA) is a remarkable biomaterial most extensively used in biomedical applications due to their properties. This review highlighted the synthesis and chemical structure of CA polymer as well as focused on the mechanical, chemical, thermal, biocompatible, and biodegradable properties of electrospun CA nanofibers. These properties are essential in the evaluation of the CA nanofibers and provide information as a reference for the further utilization and improvement of CA nanofibers. Moreover, we have summarized the use of electrospun CA nanofibers in the drug delivery system as a carrier for drugs and classify them according to the drug class, including anti-inflammatory, anticancer, antioxidant, antimicrobial agents, vitamins and amino acids. Our review has been concluded that CA nanofibers cannot wholly be biodegraded within the human body due to the absence of cellulase enzyme but degraded by microorganisms. Hence, the biodegradation of CA nanofibers in vivo has addressed as a critical challenge.

Item Type:	Article
Uncontrolled Keywords:	Cellulose acetate Biocompatible Biodegradable Electrospun nanofiber Drug delivery Electrospinning
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering Technology > Department of Chemical Engineering Technology
Depositing User:	Mr. Shahrul Ahmad Bakri
Date Deposited:	28 Mar 2022 01:18
Last Modified:	28 Mar 2022 01:18
URI:	http://eprints.uthm.edu.my/id/eprint/6818

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