Siam-weeb based gelatin electrospun scaffolds

Mohamed, Nor Shamsiah and Jun Ham, Jun Ham and Ab-Rahim, Sharaniza and Cheng, Yee Low and Ching, Theng Koh (2022) Siam-weeb based gelatin electrospun scaffolds. Malaysian Journal of Microscopy, 18 (1). pp. 147-157. ISSN 1823-7010

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Abstract

Siam weed (Chromolaena odorata) is a traditional herb used to soothe burns and scars and potentially improve dressing and tissue-engineered construct healing ability. The use of Siam weed is mainly in the form of extract. The state of liquid extract limits the use of Siam weed compared to the state of gels and membrane. However, the development of the hybrid of Siam weed in gel and membrane form is lacking. In this study, Siam weed was harvested and made into aqua extracts. The biocompatibility of the aqua extract with various concentrations was tested using Cell Proliferation Assay. The aqua extract was then incorporated into the gelatin solution and spun into nanofibers using an electrospinning technique. The cell proliferation study shows maximum cell proliferation at the 25 μg/ml concentration. The scanning electron microscope images of the electrospun scaffolds show fibrous networks’ microstructures without beads. The concentration of the hybrid solution was found to affect the morphology of the nanofibers by having diameters in the range of 160 ± 90 to 250 ± 150 nm. The Siam-weed-based gelatin electrospun scaffolds provide a native-like microenvironment and potentially improve wound healing ability for biomedical application.

Item Type:	Article
Uncontrolled Keywords:	Ssiam weed; electrospinning; gelatin; nanofiber, tissue engineering.
Subjects:	T Technology > T Technology (General) > T11.95-12.5 Industrial directories
Divisions:	Faculty of Mechanical and Manufacturing Engineering > Advanced Manufacturing and Materials Centre
Depositing User:	Mr. Abdul Rahim Mat Radzuan
Date Deposited:	05 Oct 2022 07:02
Last Modified:	05 Oct 2022 07:02
URI:	http://eprints.uthm.edu.my/id/eprint/7720

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