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Effects of RAFT agent on the selective approach of molecularly imprinted polymers

Asman, Saliza and Mohamad, Sharifah and Muhamad Sarih, Norazilawati (2015) Effects of RAFT agent on the selective approach of molecularly imprinted polymers. Polymers, 7. pp. 484-503. ISSN 20734360

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Official URL: doi:10.3390/polym7030484

Abstract

Two types of reversible addition-fragmentation chain transfer molecularly imprinted polymers (RAFT-MIPs) were synthesized using different monomers, which were methacrylic acid functionalized β-cyclodextrin (MAA-β-CD) and 2-hydroxyethyl methacrylate functionalized β-cyclodextrin (HEMA-β-CD), via reversible addition-fragmentation chain transfer (RAFT) polymerization, and were represented as RAFT-MIP(MAA-β-CD) and RAFT-MIP(HEMA-β-CD), respectively. Both RAFT-MIPs were systematically characterized using Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Brunauer-Emmett-Teller (BET), and rebinding experimental study. The results were compared with MIPs synthesized via the traditional radical polymerization (TRP) process, and were represented as MIP(MAA-β-CD) and MIP(HEMA-β-CD). Morphology results show that RAFT-MIP(MAA-β-CD) has a slightly spherical feature with a sponge-like form, while RAFT-MIP(HEMA-β-CD) has a compact surface. BET results show that the surface area of RAFT-MIP(MAA-β-CD) is higher than MIP(MAA-β-CD), while the RAFT-MIP(HEMA-β-CD) surface area is lower than that of MIP(HEMA-β-CD). Rebinding experiments indicate that the RAFT agent increased the binding capacity of RAFT-MIP(MAA-β-CD), but not of RAFT-MIP(HEMA-β-CD), which proves that a RAFT agent does not always improve the recognition affinity and selective adsorption of MIPs. The usability of a RAFT agent depends on the monomer used to generate potential MIPs.

Item Type: Article
Uncontrolled Keywords: Molecularly imprinted polymer; methacrylic acid functionalized β-cyclodextrin; 2-hydroxyethyl methacrylate functionalized β-cyclodextrin; RAFT agent
Subjects: T Technology > TP Chemical technology > TP1080-1185 Polymers and polymer manufacture
Depositing User: Mr. Mohammad Shaifulrip Ithnin
Date Deposited: 06 Sep 2018 01:58
Last Modified: 06 Sep 2018 01:58
URI: http://eprints.uthm.edu.my/id/eprint/10363
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