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Compressive forces of cell induced longitudinal deformation to the liquid crystal surface

Soon, Chin Fhong and Tee, Kian Sek and Youseffi, Mansour and Clive, Morgan Thomas Denyer (2015) Compressive forces of cell induced longitudinal deformation to the liquid crystal surface. In: International Conference on Electrical and Electronic Engineering 2015 (IC3E 2015), 10-11 August 2015 , Melaka, Malaysia.

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Abstract

The ability of a cell to contract plays an important role in determining the ability of the cell to migrate, proliferate and associating with other cells. The transduction of the force in soft substrate such as the liquid crystal surface is a method proposed to study the traction forces of single cells. In this work, finite element method was used to study the compressive forces induced by the keratinocyte to the liquid crystal surface via the anchorage of focal contacts. The constitutive finite element model of the liquid crystal-focal contacts was established. The stress and displacement were analyzed using linear static stress analysis for a quiescent cell. The data for lateral displacements obtained from the experiment were provided as inputs to develop the model and verified through the output acquired for both simulation and experiment. The simulation results indicated that the cell compressive stresses were in the range of 14.93 ± 1.9 nN/μm2 per focal contact. Based on the result obtained, it was suggested to model focal contact-liquid crystal interface with a compressive model that can better approximate the mechanism observed.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: compressive forces; keratinocyte; deformation; liquid crystal
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800-8360 Electronics
Divisions: Faculty of Electrical and Electronic Engineering > Department of Electronic Engineering
Depositing User: Normajihan Abd. Rahman
Date Deposited: 29 Oct 2015 06:04
Last Modified: 29 Oct 2015 06:04
URI: http://eprints.uthm.edu.my/id/eprint/7156
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