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Development of a flicking system for producing calcium alginate microbeads

Wong , Soon Chuan and Soon , Chin Fhong and Leong , Wai Yean and Tee , Kian Sek (2016) Development of a flicking system for producing calcium alginate microbeads. Jurnal Teknologi (Sciences & Engineering), 78 (6-2). pp. 103-109. ISSN 21803722

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Abstract

Microencapsulation of cells for various applications is increasing interest. A variety of microencapsulation technology has been developed to produce cells encapsulation. However, previous microencapsulation systems were associated with complex design, high voltage supply, requirements of post cleaning process and large volume of reagents. In this paper, we proposed the development of a flicking device for generating a 3D cell model in calcium alginate microbeads that has potential for pharmacological test and tissue implants. A flicking system based on a flicking device and a syringe pump has been developed for generation of calcium alginate microbeads. The size of the microbeads produced using this system can be controlled by changing the flow rate (5 to 15 µl/min) of the syringe pump and fixing the motor rotation speed of the flicking device at 90 rpm. The calcium alginate microbeads produced suing the flicking device were shown to be sized controllable (270 to 430 µm) and suitable for microencapsulation.

Item Type: Article
Uncontrolled Keywords: Flicking; calcium alginate; microbeads; pulse width modulation; motor
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Electrical and Electronic Engineering > Department of Electronic Engineering
Depositing User: Mr. Mohammad Shaifulrip Ithnin
Date Deposited: 13 Aug 2018 03:38
Last Modified: 13 Aug 2018 03:38
URI: http://eprints.uthm.edu.my/id/eprint/8616
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