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In vitro anti-acetyl cholinesterase and antioxidant activity of selected Malaysian plants

Nour, Azhari H. and Khan, Muhammad and Sulaiman, Ahmad Ziad and Batool, Tahira and Nour, Abdulrahman H. and Khan, Muhammad Mumtaz and Kormin, Faridah (2014) In vitro anti-acetyl cholinesterase and antioxidant activity of selected Malaysian plants. Asian Journal of Pharmaceutical and Clinical Research, 7 (3). pp. 93-97. ISSN 2455-3891

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Abstract

The aim of this study is to discover and identify the potential plant extracts that could be vital against Alzheimer’s disease (AD). It is a neurodegenerative disease affecting the brain. The most promising target for the symptomatic treatment and slowing of AD progression is cholinesterase inhibitors from plants. To evaluate the antioxidant and anti-acetylcholinesterase (AChEI) activities of leaves and roots macerated and refluxed with ethanol extracts, from four medicinal plants, namely; C.asiatica, M.pudica, C.pumila,and L.camara. DPPH and β-carotene assays were used to determine antioxidant activity; whereas Ellman’s colorimetric method was adopted to quantify AChEI activity. Among all tested samples, the refluxed ethanol extract ofM.pudicaleaves exhibited the highest AChEI activity (IC50 = 0.0114 mg/ml) whereas, M. pudica roots showed high antioxidant activity (DPPH; IC50 = 0.0102 mg/ml). Results reveal that all plant extracts studied possess anti-oxidant properties. Most potent extracts could be a lead to novel antioxidants and acetyl cholinesterase inhibitors, for the treatment of AD.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease (AD); Acetylcholinesterase activity; Antioxidant activity; β-carotene; DPPH; Medicinal plants.
Subjects: S Agriculture > SB Plant culture
Divisions: Faculty of Applied Science and Technology > Department of Humanities
Depositing User: Normajihan Abd. Rahman
Date Deposited: 28 Feb 2018 06:48
Last Modified: 28 Feb 2018 06:48
URI: http://eprints.uthm.edu.my/id/eprint/9770
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