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Phytochemical constituents, antioxidant and antiproliferative properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia

Abu Bakar, Mohd Fadzelly and Abdul Karim, Fifilyana and Suleiman, Monica and Isha, Azizul and Rahmat, Asmah (2015) Phytochemical constituents, antioxidant and antiproliferative properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia. Evidence-Based Complementary and Alternative Medicine, 2015. pp. 1-9. ISSN 1741427X

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Abstract

The study aimed to investigate the phytochemical contents, antioxidant and antiproliferative activity of 80% methanol extract of Lepidozia borneensis.The total phenolic and total flavonoid contents were analysed using Folin-Ciocalteu and aluminium chloride colorimetric methods. Antioxidant properties were evaluated by using FRAP, ABTS, and DPPH assays while the effects of L. borneensis on the proliferation ofMCF-7 cell line were evaluated by usingMTT assay.The results showed that the total phenolic and flavonoid contents were 12.42 ± 0.47mg GAE/g and 9.36 ± 1.29mg CE/g, respectively. The GC-MS analysis revealed the presence of at least 35 compounds.The extract was found to induce cytotoxicity against MCF-7 cell line with IC50 value of 47.33 ± 7.37

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Applied Science and Technology > Department of Technolgy and Heritage
Depositing User: Mr. Mohammad Shaifulrip Ithnin
Date Deposited: 13 Aug 2018 03:20
Last Modified: 13 Aug 2018 03:20
URI: http://eprints.uthm.edu.my/id/eprint/9943
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