Abu Bakar, Mohd Fadzelly and Abdul Karim, Fifilyana and Suleiman, Monica and Isha, Azizul and Rahmat, Asmah (2015) Phytochemical constituents, antioxidant and antiproliferative properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia. Evidence-Based Complementary and Alternative Medicine, 2015. pp. 1-9. ISSN 1741427X
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Abstract
The study aimed to investigate the phytochemical contents, antioxidant and antiproliferative activity of 80% methanol extract of Lepidozia borneensis.The total phenolic and total flavonoid contents were analysed using Folin-Ciocalteu and aluminium chloride colorimetric methods. Antioxidant properties were evaluated by using FRAP, ABTS, and DPPH assays while the effects of L. borneensis on the proliferation ofMCF-7 cell line were evaluated by usingMTT assay.The results showed that the total phenolic and flavonoid contents were 12.42 ± 0.47mg GAE/g and 9.36 ± 1.29mg CE/g, respectively. The GC-MS analysis revealed the presence of at least 35 compounds.The extract was found to induce cytotoxicity against MCF-7 cell line with IC50 value of 47.33 ± 7.37
Item Type: | Article |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Applied Science and Technology > Department of Technolgy and Heritage |
Depositing User: | Mr. Mohammad Shaifulrip Ithnin |
Date Deposited: | 13 Aug 2018 03:20 |
Last Modified: | 13 Aug 2018 03:20 |
URI: | http://eprints.uthm.edu.my/id/eprint/9943 |
Statistic Details: | View Download Statistic |
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