Antibacterial Activity and Inhibition Mechanism of Red Ginger (Zingiber officinale var. rubrum) Ethanol Extract Against Pathogenic Bacteria

Siti Juariah, Siti Juariah and Abu Bakar, Fazleen Izzany and Abu Bakar, Mohd Fadzelly and Susi Endrini, Susi Endrini and Sri Kartini, Sri Kartini and Riska Surya Ningrum, Riska Surya Ningrum (2023) Antibacterial Activity and Inhibition Mechanism of Red Ginger (Zingiber officinale var. rubrum) Ethanol Extract Against Pathogenic Bacteria. Journal of Advanced Research in Applied Sciences and Engineering Technology, 30 (1). pp. 145-157. ISSN 2462-1943

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Official URL: https://doi.org/10.37934/araset.30.1.145157

Abstract

Pathogenic bacteria can interfere with the body health by producing toxic substances, damaging body tissues, multiplying and killing healthy body cells. Therefore, it is crucial to explore safe alternative treatment strategies, such as developing natural bactericidal agents to eradicate infections. Red ginger (Zingiber officinale var. rubrum) has potential as an antibacterial, so it is important to study its activity in inhibiting pathogenic bacteria. The aim of this study was to assess the antibacterial activity and inhibition mechanism of red ginger extract as an inhibitor of pathogenic bacterial infection. Methods such as dilution, Kirby-Bauer disc diffusion, and an inhibition test mechanism using a spectrophotometer and SEM were conducted in this study. Red ginger ethanol extract can inhibit the growth of Salmonela thypi, Staphylococcus epidermidis, and Streptococcus mutans at a concentration of 500 µg/mL, while Pseudomonas aeruginosa at a concentration of 250 µg/mL. Further observation of bacterial cell leakage showed that the higher the red ginger ethanol extract concentration, the higher the bacterial cell leakage. Based on SEM results, the quantity of S. thypi, S. epidermidis, and S. mutans after treatment with red ginger ethanol extract decreased, and the cell wall became wrinkled and destroyed. The ethanol extract of the red ginger rhizome can be recommended as a future antibacterial agent, especially for infections caused by pathogenic bacteria.

Item Type:	Article
Uncontrolled Keywords:	Herbal Medicine; Infection; Pathogen Bacteria; Phytotherapy
Subjects:	T Technology > T Technology (General)
Divisions:	Faculty of Applied Science and Technology > Department of Postgraduate
Depositing User:	Mr. Mohamad Zulkhibri Rahmad
Date Deposited:	30 Oct 2023 07:31
Last Modified:	30 Oct 2023 07:31
URI:	http://eprints.uthm.edu.my/id/eprint/10348

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