A review of computational approaches to predict gene functions

Swee, Kuan Loh and Swee, Thing Low and Lian, En Chai and Weng, Howe Chan and Mohamad, Mohd Saberi and Deris, Safaai and Ibrahim, Zuwairie and Kasim, Shahreen and Ali Shah, Zuraini and Mohd Jamil, Hamimah and Zakaria, Zalmiyah and Napis, Suhaimi (2018) A review of computational approaches to predict gene functions. Current Bioinformatics, 13 (4). pp. 373-386. ISSN 1574-8936

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Recently, novel high-throughput biotechnologies have provided rich data about different genomes. However, manual annotation of gene function is time consuming. It is also very expensive and infeasible for the growing amounts of data. At present there are numerous functions in certain species that remain unknown or only partially known. Hence, the use of computational approaches to predicting gene function is becoming widespread. Computational approaches are time saving and less costly. Prediction analysis provided can be used in hypotheses to drive the biological validation of gene function. Objective: This paper reviews computational approaches such as the support vector machine, clustering, hierarchical ensemble and network-based approaches. Methods: Comparisons between these approaches are also made in the discussion portion. Results: In addition, the advantages and disadvantages of these computational approaches are discussed. Conclusion: With the emergence of omics data, the focus should be continued on integrating newly added data for gene functions prediction field.

Item Type: Article
Uncontrolled Keywords: Classifier; Computational biology
Subjects: R Medicine > R Medicine (General)
T Technology > T Technology (General)
Q Science > QA Mathematics > QA299.6-433 Analysis
Divisions: Faculty of Computer Science and Information Technology > Department of Web Technology
Depositing User: UiTM Student Praktikal
Date Deposited: 14 Dec 2021 08:34
Last Modified: 14 Dec 2021 08:34
URI: http://eprints.uthm.edu.my/id/eprint/4705

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