Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery

Zainal Abidin, Hafzaliza Erny and Poh, Choon Ooi and Teck, Yaw Tiong and Marsi, Noraini and Ismardi, Abrar and Mohd Noor, Mimiwaty and Nik Zaini Fathi, Nik Amni Fathi and Abd Aziz, Norazreen and Sahari, Siti Kudnie and Sugandi, Gandi and Yunas, Jumril and Chang, Fu Dee and Majlis, Burhanuddin Yeop and Hamzah, Azrul Azlan (2020) Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery. Journal of Pharmaceutical Sciences, 109 (8). pp. 2485-2492. ISSN 0022-3549

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Official URL: https://doi.org/10.1016/j.xphs.2020.04.019

Abstract

In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict the occurrence of microneedles structure deformation. The simulation study indicated that the surface buckling deformation does not occur to the microneedle structure with the increment of the load. The microneedles with dimensions of height and diameter tip ranging from 60 to 100 μm and 1 to 4 μm, respectively had been fabricated via an etching process in a mixture of hydrofluoric acid, nitric acid, and acetic acid. Three optimized microneedles but different in the structures were fabricated via the acidic etching process. The reproducibility of three different microneedle structures was 15, 20, and 60%, respectively. Stress and buckling analyses of the fabricated microneedles were further carried out on the rat skin. The obtained experimental results show promising applications for the deep dermis, stratum corneum to epidermis layer penetration.

Item Type:	Article
Uncontrolled Keywords:	Concave conic microneedles; Stress analysis; Buckling analysis; COMSOL Multiphysics; Rat skin
Subjects:	R Medicine > R Medicine (General) > R855-855.5 Medical technology T Technology > T Technology (General)
Divisions:	Faculty of Engineering Technology > Department of Mechnical Engineering Technology
Depositing User:	Miss Afiqah Faiqah Mohd Hafiz
Date Deposited:	30 Jan 2022 01:02
Last Modified:	30 Jan 2022 01:02
URI:	http://eprints.uthm.edu.my/id/eprint/6294

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