Citric acid: a green cross-linker of biomaterials for biomedical application

Salihu, Rabiu and Abd Razak, Saiful Izwan and Ahmad Zawawi, Nurliyana and Abdul Kadir, Mohammed Rafiq and Ismail, Norjihada Izzah and Mat Nayan, Nadirul Hasraf and Jusoh, Norhana and Mohamad, Mohd Riduan (2021) Citric acid: a green cross-linker of biomaterials for biomedical application. European Polymer Journal, 146 (5).

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The application of biomaterials in biomedicine currently suffers some drawbacks, such as inflammation and immunological responses due to mismatching and/or limited compatibility. Biomaterials that are cross-linked with citric acid (CA), also called citrate-based biomaterials (CBBs), have exhibited advanced in-vitro and in-vivo material properties that make them suitable for various biomedical applications. Tunable mechanical properties, biocompatibility, and biofunctionality are among other factors that make CBBs interesting in this field. To emphasize the safety and greenness nature of CA, in this review, we have highlighted the history, potential considerations of exploration, and a summarized stage-wise criterion for developing CBBs. We also discuss several points of view about the application of CA and CBBs in many different aspects of biomedicine, such as in tissue engineering, cancer therapy, and wound dressings.

Item Type: Article
Uncontrolled Keywords: Citric acid; cross-linker; biomaterials; biomedical applications; citrate-based biomaterials; citrate-based fluorescent biomaterials
Subjects: R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation
T Technology > T Technology (General)
Divisions: Faculty of Engineering Technology > Department of Chemical Engineering Technology
Depositing User: Mr. Abdul Rahim Mat Radzuan
Date Deposited: 30 Jan 2022 01:13
Last Modified: 30 Jan 2022 01:13

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