Sodium alginate-zinc oxide nanocomposite film for antibacterial wound healing applications

Abdul Bakil, Siti Natrah and Kamal, Hazirah and Abdullah, ‪Hasan Zuhudi and Idris, ‪Maizlinda Izwana (2020) Sodium alginate-zinc oxide nanocomposite film for antibacterial wound healing applications. Biointerface Research in Applied Chemistry, 10 (5). pp. 6245-6252. ISSN 2069-5837

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Abstract

This study aims to develop sodium alginate (SA) based ZnO nanoparticles as antibacterial film for wound healing applications. As natural materials, sodium alginate has been widely investigated and used in wound healing. The ZnO nanoparticles were incorporated as antibacterial into sodium alginate with different compositions (2, 4, 6, 8, 10 ml). Solvent casting method was performed to prepare a film. The film was characterized by using Fourier Transform Infrared Spectroscopy (FT-IR), Atomic Force Microscopy (AFM) and Field Emission Scanning Electron Microscopy (FESEM). Effectiveness of antibacterial activity was carried out against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) to characterize the sample. The results from microstructure analysis indicated that as ZnO nanoparticle compositions increased, the film surface became rough. It was found that sodium alginate incorporated with ZnO had slightly higher antibacterial activities against S. aureus than E. coli. Thus, sodium alginate (SA)-Zinc oxide (ZnO) nanoparticle has the potential to be used as a wound healing material in biomedical applications.

Item Type:	Article
Uncontrolled Keywords:	Wound healing; Sodium Alginate; ZnO.
Subjects:	R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation T Technology > T Technology (General)
Divisions:	Faculty of Mechanical and Manufacturing Engineering > Department of Manufacturing Engineering
Depositing User:	Miss Afiqah Faiqah Mohd Hafiz
Date Deposited:	30 Jan 2022 01:25
Last Modified:	30 Jan 2022 01:25
URI:	http://eprints.uthm.edu.my/id/eprint/6303

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