Anti-tyrosinase Activities of Curcumin-Chitosan Gold Nanoparticles Synthesized from Beetle (Oryctes rhinoceros)

N. ALYANI ZAINOL ABIDIN, N. ALYANI ZAINOL ABIDIN and F. KORMIN, F. KORMIN and N. AKHMA ZAINOL ABIDIN, N. AKHMA ZAINOL ABIDIN and M.F. ABU BAKAR, M.F. ABU BAKAR and ADE CHANDRA IWANSYAH, ADE CHANDRA IWANSYAH (2023) Anti-tyrosinase Activities of Curcumin-Chitosan Gold Nanoparticles Synthesized from Beetle (Oryctes rhinoceros). Asian Journal of Chemistry, 35 (1). pp. 70-82.

Text J15906_9eb7f2cda47099492a4587db82d7cf2a.pdf Restricted to Registered users only Download (549kB) | Request a copy

Abstract

A breakthrough in cosmeceuticals by utilizing insects as major ingredients in cosmetic products is gaining popularity. Therefore, the interest in rare sources of ingredients, for instance, from the Oryctes rhinoceros beetle, can bring huge benefit in turning pest to wealth. In this study, curcumin was chosen as the active ingredient loaded into chitosan-gold nanoparticles (CCG-NPs). However, curcumin is unstable, has poor absorption, a high rate of metabolism and high sensitivity to light. These are all factors that contribute to the lower bioavailability of any substance to reach the target cells. Therefore, chitosan extracted from O. rhinoceros acts as a drug carrier and incorported in gold nanoparticles are used to overcome these problems. The CCG-NPs were successfully synthesized at 70 ºC for 60 min under optimal conditions of reactant ratio of 2:0.5 (0.5 mM HAuCl4:0.1% curcumin). The tyrosinase enzyme inhibition of CCG-NPs from O. rhinoceros was 66.385 ± 3.0%. Thus showing a good inhibition trait for the anti-tyrosinase assay as it is almost double the tyrosinase inhibition percentage when being compared to CCG-NPs from the commercial chitosan. Therefore, CCG-NPs from O. rhinoceros has a high potential in cosmeceutical applications as whitening agent.

Item Type:	Article
Uncontrolled Keywords:	Anti-tyrosinase activity, Chitosan nanoparticle, Beetle, Gold nanoparticles, Oryctes rhinoceros
Subjects:	T Technology > T Technology (General)
Divisions:	Faculty of Applied Science and Technology > Department of Technology and Natural Resources
Depositing User:	Mr. Mohamad Zulkhibri Rahmad
Date Deposited:	17 Jul 2023 07:31
Last Modified:	17 Jul 2023 07:31
URI:	http://eprints.uthm.edu.my/id/eprint/9170

Actions (login required)

View Item