Application of a novel widefield surface plasmon microscope in binding assays

Marlafeka, S. and Liu, S. and Abdul Jamil, M. Mahadi and Twigg, P. C. and Britland, S. T. and Denyer, M. C. T. and See, C. W. and Somekh, M. G. (2005) Application of a novel widefield surface plasmon microscope in binding assays. In: 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, 12 - 15 May 2005, Kahuku, Oahu, Hawaii, USA.

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Official URL: DOI:10.1109/MMB.2005.1548406


The present work investigates the capabilities of a novel widefield surface plasmon microscope (WSPR) and its potential applications in biology. Here in particular, we concentrate on imaging interfacial interactions between specific antibodies and the proteins laminin and fibronectin, both patterned onto prefabricated Au / Cr / glass substrates. These experiments are used to demonstrate the high sensitivity, good contrast and high lateral resolution (close to a micron) of the new system. These results indicate that our microscope may form the basis for a new generation of fast assay systems.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Surface plasmon; widefield; immunoassay; cell
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Faculty of Electrical and Electronic Engineering > Department of Electronic Engineering
ID Code:9652
Deposited By:Mr. Mohammad Shaifulrip Ithnin
Deposited On:13 Aug 2018 11:34
Last Modified:13 Aug 2018 11:34

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