Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment

Ng, Celine and Hamzah, Mohd Syahir Anwar and Abd Razak, Saiful Izwan and Abdul Sukor, Jumadi and Nayan, Nafarizal and Mat Nayan, Nadirul Hasraf (2020) Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment. Journal of Advanced Industrial Technology and Application, 1 (2). pp. 7-11. ISSN 2716-7097

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Abstract

Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal wound dressing and drug delivery carrier. In this work, polyvinyl alcohol (PVA) and poly (lactic acid) (PLA) were chosen polymer to produce wound dressing membrane through electrospinning and coating method. PVA was electrospun and then coated with PLA. Preliminary study had been conducted between 1, 4 and 8% concentration for the selection of optimum PLA coating concentration. PLA has been proposed for the use of coating materials at 4%, the coated nanofiber membrane started to exhibit high Ultimate Tensile Strength at 1022.5 ± 9.28 MPa, highest degree of swelling (1850 ± 3.7 %) and optimum water contact angle (60.9 ± 11.46 ̊). The aim of this study was to investigate the morphological properties of PVA/PLA wound dressing membrane. Based on the results from Atomic Force Microscope, PVA nanofiber coated with 4% PLA exhibit the highest value of Rq which is 0.47 ± 0.19 μm compared to neat PVA nanofibers membrane. Field Emission Scanning Electron Microscope (FE-SEM) image revealed that PVA nanofiber coated with 4% PLA shows porous fiber-like morphology and well incorporated with each other without any gap formed between them. This report clearly suggestive of the fact that synthetic biodegradable polymers such as PLA can be exploited for the synergistic combination with PVA nanofiber for wound dressing application.

Item Type:	Article
Uncontrolled Keywords:	Wound; Electrospinning; Polyvinyl Alcohol; Poly(lactic acid); Morphological
Subjects:	R Medicine > R Medicine (General) > R855-855.5 Medical technology T Technology > TP Chemical technology > TP1080-1185 Polymers and polymer manufacture
Divisions:	Faculty of Engineering Technology > Department of Electrical Engineering Technology
Depositing User:	Miss Nur Rasyidah Rosli
Date Deposited:	30 Jan 2022 08:54
Last Modified:	30 Jan 2022 08:54
URI:	http://eprints.uthm.edu.my/id/eprint/6427

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