Anti-gout potential of Malaysian medicinal plants

Abu Bakar, Fazleen I. and Abu Bakar, Mohd F. and Rahmat, Asmah and Abdullah, Norazlin and Sabran, Siti F. and Endrini, Susi (2018) Anti-gout potential of Malaysian medicinal plants. FRONTIERS IN PHARMACOLOGY, 9. pp. 1-14. ISSN 16639812

Text AJ 2018 (151).pdf Restricted to Registered users only Download (719kB) | Request a copy

Abstract

Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated.

Item Type:	Article
Uncontrolled Keywords:	xanthine oxidase inhibition; anti-gout; phytochemical; Malaysian medicinal plants; in vitro; in vivo
Subjects:	R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine T Technology > T Technology (General) Q Science > QK Botany > QK710-899 Plant physiology
Divisions:	Faculty of Applied Science and Technology > Department of Technology and Natural Resources
Depositing User:	UiTM Student Praktikal
Date Deposited:	05 Jan 2022 08:43
Last Modified:	05 Jan 2022 08:43
URI:	http://eprints.uthm.edu.my/id/eprint/5115

Actions (login required)

View Item